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教师简介

刘勇
时间:2016-12-26 11:29:28 阅读量:
    职称职务:教授
学科专业:细胞生物学
研究方向:细胞应激与代谢疾病
实验室位置:澳门24小时大楼1131
联系方式:电话:027-68753463
Email: liuyong31279@whu.edu.cn

 

学习经历:

1982-1986年  北京大学生物系生物化学专业,学士
1986-1989年  北京大学生物系生物化学专业,硕士
1989-1995年  美国Rutgers新泽西州立大学微生物学和分子遗传学系,博士

主要工作经历与任职情况:
1995-2000年  美国加州大学Santa Barbara分校分子、细胞与发育生物学系,博士后
2000-2003年  美国加州AlleCure/Mannkind免疫生物技术集团研发部,Senior Scientist
2003.7-2015.8  中科院上海生命科学研究院营养科学研究所,研究组长,研究员,博士生导师,“百人计划”择优支持
2015.9- 武汉大学澳门24小时,教授,博士生导师


主要社会兼职:
2008-2015年 中科院营养与代谢重点实验室副主任
2008-2015年 中科院上海生命科学研究院学术委员会委员
2011-2015年 中科院上海营养科学研究所副所长
2012年-至今   J. Biol. Chem., Editorial Board Member
2013年-至今   中国老年保健医学研究会老年健康与转化医学分会,常务委员

主要研究领域及兴趣:
1) 细胞应激与糖脂代谢紊乱的分子机制
2) 内质网应激与免疫炎性疾病的分子基础
  致力于研究糖脂代谢调控的生理学机制和慢性炎性疾病的病理学基础。利用动物模型,在生理学水平上探索营养失衡、内质网应激与糖脂代谢紊乱的机制关联,深入了解免疫炎性疾病发生发展的分子病理学基础,为肥胖、2型糖尿病及脂肪肝等慢性疾病的防治探寻新的干预靶标。


主持课题项目:
2012-2016 国家重大科学研究973计划:“营养失衡导致脂代谢紊乱疾病的病理生理学机制与早期干预研究”,首席科学家
2013-2017 国家自然科学基金重点项目:“细胞内质网应激信号通路在代谢适应性调节中的生理学功能和机制”,负责人
2015-2019 国家自然科学基金重点国际合作项目:“内质网应激与线粒体损伤在慢性肝病发生发展中的作用机制”,负责人

代表性论文:
1) Liu Y, Shao M, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, Rui L,   Liu Y*. (2015) Role for the Endoplasmic Reticulum Stress Sensor IRE1α in Liver Regenerative Responses.   J Hepatol. 62:590-98.

2) Zhang HS, Chen Y, Fan L, Xi QL, Wu GH, Li XX, Yuan TL, He SQ, Yu Y, Shao ML, Liu Y, Bai CG, Ling ZQ, Li M,   Liu Y*, Fang J   *. (2015) The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis. J Biol Chem. 290:15327-36.

3) Jiang S, Yan C, Fang QC, Shao ML, Zhang YL, Liu Y, Deng YP, Shan B, Liu JQ, Li HT, Yang L, Zhou J, Dai Z,   Liu Y*, Jia WP*. (2014) Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts ER stress-induced Hepatic Steatosis.   J Biol Chem. 289:29751-65. (Chosen as one of the   Best JBC Papers of the Year)

4) Xu T, Yang L, Yan C, Wang X, Huang P, Zhao F, Zhao L, Zhang M, Jia W, Wang X*,   Liu Y*. (2014) The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells.   Cell Res. 24:1137-40.

5) Shao M, Shan B, Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, Jia W, Li J, Li J, Rui L, Yang L,   Liu Y*. (2014) Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.   Nat Commun. 5:3528.

6) Zhang Q, Liu B, Cheng Y, Meng Q, Xia T, Jiang L, Chen S,   Liu Y*, Guo F*. (2014) Leptin signaling is required for leucine deprivation-enhanced energy expenditure.   J Biol Chem. 289:1779-87.

7) Zhang C, Li S, Yang L, Huang P, Li W, Wang S, Zhao G, Zhang M, Pang X, Yan Z,   Liu Y*, Zhao L*. (2013) Structural modulation of gut microbiota in life-long calorie-restricted mice.   Nat Commun. 4:2163.

8) Zhang Y, Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L,   Liu Y*. (2012) A Role for Protein Inhibitor of Activated STAT1 (PIAS1) in Lipogenic Regulation through SUMOylation-independent Suppression of Liver X Receptors.   J Biol Chem. 287(45):37973-85.

9) Yu Y, Sun Y, He S, Yan C, Rui L, Li W,   Liu Y*. (2012) Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster.   Mol Cell Biol.   32:3610-23.

10) Zhou B, Yang L, Li S, Huang J, Chen H, Hou L, Wang J, Green CD, Yan Z, Huang X, Kaeberlein M, Zhu L, Xiao H,   Liu Y* and Han JD*. (2012) Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions.   Proc. Natl. Acad. Sci. U.S.A. Plus   109:E1201-9.

11) Mao T, Shao M, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Yi, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W and   Liu Y*. (2011) PKA Phosphorylation Couples Hepatic IRE1a to Glucagon Signaling in Glucose Metabolism.   Proc. Natl. Acad. Sci. U.S.A   . 108:15852-7.

12) Yang L, Zhao L, Gan Z, He Z, Xu J, Gao X, Wang X, Han W, Chen L, Xu T, Li W*,   Liu Y*. (2010)   Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis.   FASEB J. 24:3720-32.

13) Wang Q, Li S, Jiang L, Zhou Y, Li Z, Shao M, Li W,   Liu Y*. (2010) Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid compositions of mice.   J. Lipid Res. 51:2516-26.

14) You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke Z, Li W, Li C* and   Liu Y*. (2010) Tyr   985 signaling of leptin receptor as an age/diet-dependent switch in regulation of energy balance.   Mol. Cell. Biol. 30:1650-9.
(Highlighted by   Editor’s Choice,   Science 139, 141, 2010 and   Science Signaling 3, ec95, 2010)

15) Song W, Ren D, Li W, Jiang L, Cho KW, Huang P, Fan C, Song Y,   Liu Y* and Rui L*. (2010) SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals.   Cell Metab. 11:427-37.

16) Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W*,   Liu Y*. (2010) A crucial role for RACK1 in regulation of glucose-stimulated IRE1α activation in pancreatic β-cells.   Sci. Signal. 3, ra7.
(Highlighted in   Perspective,   Science Signaling 3, pe7, 2010)

17) Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W and   Liu Y*   . (2009) Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.   Hepatology 49:1166-75.

18) Jiang L, You J, Yu X, Gonzalez L, Yu Y, Wang Q, Yang G, Li W, Li C*,   Liu Y*   . (2008) Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis.   Proc. Natl. Acad. Sci. U.S.A   . 105: 18619-24. (Highlighted by   Nature China, 2008)

19) Qi Q, Yu Z, Ye X, Zhao F, Huang P, Hu F, Franco OH, Wang J, Li H,   Liu Y*, Lin X*. (2007) Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people.   J. Clin. Endocr. Metab. 92:4827-34.

20) Gan Z, Zhao L, Yang L, Huang P, Zhao F, Li W,   Liu Y*. (2006) RNA editing by ADAR2 is metabolically regulated in pancreatic islets and β-cells.   J. Biol. Chem. 281:33386-94   .
 
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