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教师简介

程汉华
时间:2016-12-26 11:27:57 阅读量:
  职称职务:教授、博士生导师
 专业: 细胞生物学
 研究方向:动物分子细胞生物学
  实验室位置:澳门24小时大楼4114和4116号房间
  联系电话:027-68756253
 传  真:027-68756253
 Email: hhcheng@whu.edu.cn


教育经历:
1979-1983 华中农业大学,学士学位
1983-1986 四川农业大学,硕士学位
1990-1993 华西医科大学,博士学位


工作经历:
1986-1990 华中农业大学,助教
1993-至今 武汉大学,讲师、副教授、教授、博士生导师


主要研究领域和兴趣:
我们的研究领域是动物及人类分子细胞生物学。通过人类及多模式物种(主要是小鼠,斑马鱼和黄鳝)研究早期胚胎发育、分化和器官形成过程中所涉及的众多基因的时空表达与调控;研究基因-发育-进化等生命本质, 尤其关注生殖与发育、细胞分化、干细胞命运及小RNA等生命活动及其分子病理机制。

教学情况:
1. 生物化学, 90学时,生科院本科生必修课,2001-至今
2. 细胞生物学实验课,54学时,生科院本科生必修课,2004-2006
3. 生物技术导论,18学时,全校通识课 2008-2009
4. 动物分子细胞生物学,36学时,研究生专业必修课 2003-至今


近十年发表论文和著作:

1. Sheng Y., Song Y., Li Z., Wang Y., Lin H., Cheng H., Zhou R., RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly. Cell Death Differ. 2018; 25(5):918-934.

2. Song Y., Shang D., Cheng H., Zhou R., The small GTPase RAB37 functions as an organizer for autophagosome biogenesis. Autophagy. 2018; 14(4): 702-714.

3. Zhao X, Luo M, Li Z, Zhong P, Cheng Y, Lai F, Wang X, Min J, Bai M, Yang Y, Cheng H, Zhou R., Chromosome-scale assembly of the Monopterus genome. Gigascience. 2018;7(5):1-9.

4. Liu J., Shang D., Xiao Y., Zhong P., Cheng H., Zhou R., Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice. J. Biol. Chem. 2017; 292(39):16003-16013.

5. Luo M, Zhao X, Song Y, Cheng H, Zhou R., Nuclear autophagy: An evolutionarily conserved mechanism of nuclear degradation in the cytoplasm. Autophagy. 2016;12(11):1973-1983.

6. Xiao Y, Gao M, Gao L, Zhao Y, Hong Q, Li Z, Yao J, Cheng H, Zhou R., Directed Differentiation of Zebrafish Pluripotent Embryonic Cells to Functional Cardiomyocytes. Stem Cell Reports. 2016;7(3):370-82.

7. Yuan J., Zhang Y., Sheng Y., Fu X., Cheng H., Zhou R., MYBL2 guides autophagy suppressor VDAC2 to the developing ovary to inhibit autophagy through a complex of VDAC2 /BECN1/ BCL2L1 in mammals. Autophagy, 2015, 11(7):1081-1098.

8. Fu X., Cheng Y., Yuan J., Huang C., Cheng H., Zhou R., Loss-of-function mutation in the X-linked TBX22 promoter disrupts an ETS-1 binding site and leads to cleft palate. Hum. Genet. 2015, 134(2):147-158.

9. Chen K., Huang C., Yuan J., Cheng H., Zhou R., Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells. Mol Biol Evol. 2014,31(8):2194-211.

10. Zuo Z, Peng D, Yin X, Zhou X, Cheng H, Zhou R., Genome-Wide Analysis Reveals Origin of Transfer RNA Genes from tRNA Halves. Mol Biol Evol. 2013,30(9):2087-98.

11. Hou Y, Yuan J, Zhou X, Fu X, Cheng H, Zhou R., DNA Demethylation and USF Regulate the Meiosis-Specific Expression of the Mouse Miwi. PLoS Genet. 2012;8(5):e1002716.

12. Zhou F, Zhao W, Zuo Z, Sheng Y, Zhou X, Hou Y, Cheng H, Zhou R., Characterization of androgen receptor structure and nucleocytoplasmic shuttling of the rice field eel. J. Biol. Chem. 2010, 285(47):37030-40.

13. Zhou X, Zuo Z, Zhou F, Zhao W, Sakaguchi Y, Suzuki T, Suzuki T, Cheng H, Zhou R., Profiling sex-specific piRNAs in zebrafish. Genetics. 2010,186(4):1175-85.

14. Ying M, Chen B, Tiana Y, Hou Y, Li Q, Shang X, Sun J, Cheng H., Zhou R., Nuclear import of human sexual regulator DMRT1 is mediated by importin-β. BBA Mol. Cell Res. 2007, 1773(6):804-813.

15. Huang X, Guo Y, Shui Y, Gao S, Yu H,, Cheng H., Zhou R., Multiple alternative splicing and differential expression of Dmrt1 in gonad transformation during sex reversal of the rice field eel. Biol. Reprod. 2005, 73: 1017–1024.

16. Cheng H., Ying m., Tian Y., Guo Y., McElreavey K., Zhou R., Transcriptional diversity of DMRT1 (dsx- and mab3-related transcription factor 1) in human testis. Cell Res. 2006, 16:389-393.

17. 周荣家,程汉华,编著《转基因动物技术与应用》,武汉大学出版社,1997。

18. 周荣家等,译著《发育原理》,高等教育出版社,2009。

19. 张楚富主编,程汉华 刘德立副主编,《生物化学原理》,高等教育出版社,2011。

 以上研究成果由973项目, 国家自然科学基金项目和教育部“新世纪优秀人才计划”资助。

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